2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldose Reductase

Aldose Reductase

Aldose Reductase

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Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney.

Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N14431
    Salfredin C2
    		Inhibitor
    Salfredin C2 is an aldose reductase inhibitor.
    Salfredin C2
  • HY-N14451
    Salfredin C1
    		Inhibitor
    Salfredin C1 is an aldose reductase inhibitor.
    Salfredin C1
  • HY-50289R
    Sorbinil (Standard)
    		Inhibitor
    Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
    Sorbinil (Standard)
  • HY-N4089R
    Quercetin 3-gentiobioside (Standard)
    		Inhibitor
    Quercetin 3-gentiobioside (Standard) is the analytical standard of Quercetin 3-gentiobioside (HY-N4089). This product is intended for research and analytical applications. Quercetin 3-gentiobioside is a flavonoid found in Artemisia iwayomogi. Quercetin 3-gentiobioside inhibits aromatase with an Ki of 46.77 nM. Quercetin 3-gentiobioside inhibits aldose reductase (AR) and the formation of advanced glycation end products (AGEs), with IC50 values of 10.60 μM and 109.46 μM, respectively. Quercetin 3-gentiobioside inhibits proliferation of cancer cells and fibroblast-like synoviocytes. Quercetin 3-gentiobioside can be used for the research of cancer, such as lung carcinoma.
    Quercetin 3-gentiobioside (Standard)
  • HY-175862
    ALR2-IN-9
    		Inhibitor
    ALR2-IN-9 is a potent ALR2 inhibitor (IC50 = 21.8 nM) with excellent antioxidant activity (EC50 for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species (ROS)/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD. ALR2-IN-9 regulates PI3K/Akt/Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO4- and H2O2-induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1. ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research.
    ALR2-IN-9
  • HY-183923
    SX 3202
    		Inhibitor
    SX 3202 is an aldose reductase inhibitor. SX 3202 can be used for the research of diabetic complications.
    SX 3202
  • HY-N14419
    Salfredin C3
    		Inhibitor
    Salfredin C3 is an aldose reductase inhibitor.
    Salfredin C3
  • HY-N14449
    Salfredin A4
    		Inhibitor
    Salfredin A4 is an aldose reductase inhibitor.
    Salfredin A4
  • HY-N0309R
    Soyasaponin Ba (Standard)
    		Inhibitor
    Soyasaponin Ba (Standard) is the analytical standard of Soyasaponin Ba (HY-N0309). Soyasaponin Ba is a soyasaponin that can be isolated from Phaseolus vulgaris, acts as an aldose reductase inhibitor (ARI). Soyasaponin Ba activates Akt/GSK3β/β-catenin signaling pathway, reduces lipid accumulation, lowers ROS generation, improves mitochondrial membrane potential, ATP levels, and morphology, and inhibits apoptosis. Soyasaponin Ba can be used for the research of lipid accumulation and secondary diabetic complications.
    Soyasaponin Ba (Standard)
  • HY-16255R
    Imirestat (Standard)
    		Inhibitor
    Imirestat (Standard) is the analytical standard of Imirestat. This product is intended for research and analytical applications. Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
    Imirestat (Standard)
  • HY-N12472
    Floramanoside C
    		Inhibitor
    Floramanoside C shows 2,2-diphenyl-1-picrylhydrazyl scavenging and aldose reductase inhibitory activities.
    Floramanoside C
  • HY-W319094
    4′-Hydroxyflavone
    		Inhibitor
    4′-Hydroxyflavone (compound 50) can inhibit aldose reductase, with IC50 12 μM.
    4′-Hydroxyflavone
  • HY-155164
    WF-3681
    		Inhibitor
    WF-3681 (compound 1) is an aldose reductase inhibitor and a fungal metabolite.
    WF-3681
  • HY-N14401
    Salfredin B11
    		Inhibitor
    Salfredin B11 is an aldose reductase inhibitor.
    Salfredin B11
  • HY-W011786
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
    		Inhibitor
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole is an inhibitor of larval settlement in marine organisms, demonstrating low toxicity while effectively inhibiting the metamorphosis of species such as barnacles, bryozoans, and polychaetes. 2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole also exhibits activity as an aldose reductase (ALR2) inhibitor, indicating potential therapeutic applications in diabetes-related complications.
    2-Chloro-1-(4-fluorobenzyl)-1H-benzo[d]imidazole
  • HY-B1202A
    Alrestatin sodium
    		Inhibitor
    Alrestatin (AY-22284) sodium is an aldose reductase inhibitor. Alrestatin sodium reduces fructose levels in the uterine fluid of mice. Alrestatin sodium interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin sodium decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin sodium enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin sodium can be used in studies related to diabetes and reproductive diseases.
    Alrestatin sodium
  • HY-122177
    MK181
    		Inhibitor
    MK181 is an aldose reductase (AR) inhibitor with IC50s of 0.71 μM and 4.5 μM for aldose reductase and AKR1B10, respectively. MK181 can bind into the external loop A subpocket of AKR1B10.
    MK181
  • HY-116508
    MK 319
    		Inhibitor
    MK 319 is a selective aldose reductase (AR) inhibitor with an IC50 of 0.3 μM. MK 319 can be utilized in diabetes research.
    MK 319
  • HY-W739812
    Carboxy finasteride
    		Inhibitor
    Carboxy finasteride is a metabolite of the 5α-reductase inhibitor Finasteride (HY-13635). Finasteride is biotransformed by cytochrome P450 (CYP3A4) and is successively oxidized to Hydroxy finasteride and Carboxy finasteride. Carboxy finasteride is the major metabolite in urine, while Hydroxy finasteride is the major metabolite in plasma.
    Carboxy finasteride
  • HY-181519
    ALR2/α-GLY-IN-1
    		Inhibitor
    ALR2/α-GLY-IN-1 is a potent dual-target inhibitor that targets aldose reductase ALR2 and α-glucosidase (IC50 values are 0.72 μM and 0.82 μM, respectively; Ki values are 1.67 μM and 1.37 μM, respectively). ALR2/α-GLY-IN-1 also acts as a DNA binder, which stably interacts with calf thymus double-stranded DNA through non-covalent interactions such as groove-binding mode and water-bridged hydrogen bonds. ALR2/α-GLY-IN-1 can be used in studies related to diabetes and its complications.
    ALR2/α-GLY-IN-1
Cat. No. Product Name / Synonyms Application Reactivity